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Cell Migration in Development and Disease
BIOL 322
Spring 2022
Section: 01  

What do the formation of an embryo, the healing of a wound, the surveillance of the immune system, and the invasion of metastatic cancer all have in common? Each of these processes requires the coordinated movement of cells, alone or in groups. In this course, we will learn how and why cells move, and explore what happens when they stop moving properly. We will build up our knowledge from "small" to "large," spanning biological scales from molecules to tissues. Topics will include: (1) the biomolecules of migration: cytoskeleton, focal adhesions, molecular motors; (2) cellular locomotion: protrusion, adhesion, contraction, retraction; (3) cell mechanics and force generation; (4) collective motions during morphogenesis and repair; (5) mechanisms for steering migration: chemotaxis, haptotaxis, galvanotaxis, durotaxis, etc; (6) cancer as a disease of aberrant cell migration. Throughout the course we will emphasize model systems, experimental design, and technology and measurement techniques. We will focus on seminal works, with attention paid to how these works rippled forward in time, along with cutting edge research.
Credit: 1 Gen Ed Area Dept: NSM BIOL
Course Format: DiscussionGrading Mode: Graded
Level: UGRD Prerequisites: MB&B181
Fulfills a Major Requirement for: (BIOL)(INFO-MN)(MOBI-MN)
Past Enrollment Probability: 90% or above

Last Updated on MAY-28-2024
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