Fall 2021 not offered
This course is addressed to undergraduate and graduate students interested in biological chemistry and structural biology. The course presents thermodynamic methods currently used to relate structure to function in biological molecules. Topics include binding curves, chemical ligand linkages, binding polynomial, cooperativity, site-specific binding processes, and allosteric effects. Several models for allosteric systems, such as the Monod-Wyman-Changeux model, the induced-fit model, and the Pauling model, are analyzed in detail. Applications of these models are illustrated for functional regulation of respiratory proteins and for protein-nucleic-acid complexes involved in control of gene expression.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: |
||Prerequisites: (MATH121 AND MATH122)
||Fulfills a Major Requirement for: (CHEM-MN)(CHEM-Track A)(CHEM-Track B)(MB&B)(MOBI-MN)
Wyman & Gill, BINDING AND LINKAGE: FUNCTIONAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES, University Science Books, 1990.
DeCera, THERMODYNAMIC THEORY OF SITE-SPECIFIC BINDING PROCESSES IN BIOLOGICAL MACROMOLECULES, Cambridge University Press, 1995.
|Examinations and Assignments: |
One midterm exam; final exam.
|Additional Requirements and/or Comments: |
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