Mechanisms of Chromosome Segregation
MB&B 314
Fall 2008 not offered
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| Crosslisting:
MB&B 514 |
This course will focus on various aspects of eukaryotic chromosome segregation and genome stability, with particular focus on the centrosome/spindle pole body, the mitotic spindle apparatus, and the telomeric ends of linear chromosomes. We will discuss the physical architecture of these structures, the core molecular components comprising them, and the remarkable degree of functional conservation between these structures from organisms as diverse as yeast and humans. We will explore how the physical structure of these cellular structures undergoes extensive, dynamic alteration to facilitate different functions in various biological contexts. An emphasis will be placed on current experimental strategies used for identification of critical proteins associated with these structures and the powerful set of molecular and cellular methods available for characterizing their functions in both normal and diseased cells. |
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Essential Capabilities:
None |
| Credit: 1 |
Gen Ed Area Dept:
None |
| Course Format: Discussion | Grading Mode: Graded |
| Level: UGRD |
Prerequisites: None |
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Fulfills a Requirement for: None |
Major Readings:
Alberts, et. al., MOLECULAR BIOLOGY OF THE CELL, 4th edition
and current literature
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Examinations and Assignments:
Final Exam |
| Drop/Add Enrollment Requests | | | | | |
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