Molecules to Medicine
CHEM 342
Spring 2017
| Section:
01
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This course will explore the process of drug development, including target selection, lead discovery using computer-based methods and combinatorial chemistry/high-throughput screening, organic synthesis, bioavailability, clinical trials, and other factors (some economics and politics) involved in bringing a drug to the marketplace. Critical consideration of the variables to contend with at each step will be described and discussed, including aspects of research ethics and patent law. The basic science of molecular recognition, computer-aided drug design, and the role of factors from synthetic chemistry to toxicology will be presented. Case studies of the development of drugs recently successful in making the journey from molecule to medicine will be discussed, as well as the story of some that did not, and why. Emerging new design strategies such as fusion-protein therapies, crisper technology, and enhanced use of rational design and combinatorial methods will be emphasized, and how pharmaceutical research is evolving in the post-genomic era, particularly with biologics. Job opportunities in the pharmaceutical industry will be discussed. |
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| Credit: 1 |
Gen Ed Area Dept:
NSM CHEM |
| Course Format: Lecture / Discussion | Grading Mode: Graded |
| Level: UGRD |
Prerequisites: CHEM141 OR CHEM143 OR CHEM251 |
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Fulfills a Requirement for: (MB&B)(MOBI-MN) |
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Past Enrollment Probability: Not Available |
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