Metals, Metalloenzymes, and Disease
MB&B 536
Spring 2027
| Section:
01
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| Crosslisting:
MB&B 336 |
This course examines how transition metals regulate cellular biochemistry and how disruptions in metal homeostasis contribute to human disease. Through analysis of primary scientific literature and active discussions, students will explore the roles of metals such as copper, iron, and zinc in enzymatic activity, mitochondrial function, redox balance, and gene regulation. Emphasis is placed on understanding how metal deficiency, overload, or mislocalization leads to developmental and degenerative disorders. Case studies include Wilson disease, Menkes disease, mitochondrial myopathies, neurodegenerative diseases, and cancer. Students will connect molecular mechanisms to tissue dysfunction and clinical outcomes while developing skills in critical analysis of experimental design and data interpretation. |
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| Credit: 1 |
Gen Ed Area Dept:
NSM MB&B |
| Course Format: Discussion | Grading Mode: Graded |
| Level: GRAD |
Prerequisites: MB&B191 AND MB&B208 AND CHEM251 |
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Fulfills a Requirement for: None |
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Past Enrollment Probability: Not Available |
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