This course is designed to explore the intricate relationship between the aging process and the nervous system. As our population ages, understanding the underlying neurobiology of aging becomes increasingly important. This course delves into the physiological, cellular, and molecular aspects of how the nervous system changes over time and the impact of these changes on cognition, behavior, and overall well-being.
This course will introduce the student to the study of aging (gerontology) and the effects of normal aging and pathological aging on the nervous system. We will discuss general concepts of aging, and biochemical, physiological, and behavioral age-associated changes in the motor, sensory, cognitive, and neuroendocrine systems. By the end of the course, the student should have a clear understanding of what aging is and what effects it has on normal brain function. In class, I will introduce the topic with slide presentation and after that, we will discuss the topic based on the scientific article discussion. After the last class, students will have extensive opportunities for feedback and will write a project and present it in class as an oral presentation. Student evaluation will include weekly quizzes, project, a midterm and final exams, and class participation/attendance.
Course Objectives:
By the end of this course, students will:
1. Gain a Comprehensive Understanding: Develop a comprehensive understanding of the neurobiological processes associated with aging, including neurodegenerative diseases.
2. Explore Structural Changes: Examine structural changes in the aging brain, such as alterations in neuron density, synapse formation, and brain volume.
3. Analyze Functional Changes: Analyze functional changes in the aging nervous system, including changes in memory, cognition, sensory perception, and motor function.
4. Study Neurodegenerative Diseases: Investigate common neurodegenerative diseases associated with aging, such as Alzheimer's disease, Parkinson's disease, and age-related macular degeneration.
5. Explore Cellular and Molecular Mechanisms: Explore the cellular and molecular mechanisms underlying age-related changes in the nervous system, including oxidative stress, inflammation, and genetic factors.
6. Examine Potential Interventions: Review potential interventions and strategies to promote healthy aging and delay or mitigate age-related neurobiological changes. |