Mechanisms of DNA Damage and Repair|
Students taking this course will learn about the sources and consequences of DNA damage and about the biochemical processes dedicated to DNA repair in prokaryotes and eukaryotes, including humans. Presentation and discussion of current research on DNA damage, repair, and mutagenesis with emphasis on protein structure-function and enzyme kinetics, as well as diseases associated with defective DNA repair, will be an important part of the course.
The course will require students to learn methods for analyzing thermodynamic and kinetic data, and interpreting the data to assess or develop model mechanisms of protein action.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Student Option|
||Fulfills a Major Requirement for: (MB&B)(MOBI-MN)
||Past Enrollment Probability: Not Available
|Major Readings: Wesleyan RJ Julia Bookstore
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz, Tom Ellenberger, DNA REPAIR AND MUTAGENESIS, 2nd edition (ASM Press, 2005)
Research articles from journals such as Science, Nature, PNAS USA, Cell, EMBO J, Molecular Cell, etc.
|Examinations and Assignments: |
In-class participation, one mid term exam and a take-home final exam, as well as a few short problem-solving/essay assignments.
|Additional Requirements and/or Comments: |
This course is designed for life science graduate students and majors. However any student with an interest in/some knowledge of life sciences, and dedicated to learning is welcome.
|Instructor(s): Hingorani,Manju Times: ..T.R.. 10:30AM-11:50AM; Location: HALL84; |
|Total Enrollment Limit: 40||SR major: 8||JR major: 8|| || |
|Seats Available: 28||GRAD: 8||SR non-major: 8||JR non-major: 4||SO: 4||FR: X|
|Drop/Add Enrollment Requests|
|Total Submitted Requests: 0||1st Ranked: 0||2nd Ranked: 0||3rd Ranked: 0||4th Ranked: 0||Unranked: 0|