Protein Folding: From Misfolding to Disease
MB&B 535
Fall 2011
| Section:
01
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| Crosslisting:
MB&B 335 |
Amyloidogenesis, the process by which proteins and peptides misfold to form amyloid fibers, is at the root of several different diseases, including Parkinson's disease, Alzheimer's disease, mad cow disease, and type II diabetes to name a few. This course will focus on current research in the field that seeks to understand why a functional, well-folded protein adopts the misfolded amyloid form. In the course of discussing the misfolded nature of these proteins, we will review central elements of protein structure and stability to better understand the protein-folding landscape and the process of misfolding. We will also discuss how the process of misfolding leads to the different diseases and disease pathologies. |
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Essential Capabilities:
Logical Reasoning, Quantitative Reasoning
We will be discussing how quantitative scientific measurements lead to interpretation of scientific data.
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| Credit: .5 |
Gen Ed Area Dept:
NSM MB&B |
| Course Format: Lecture / Discussion | Grading Mode: Graded |
| Level: GRAD |
Prerequisites: None |
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Fulfills a Major Requirement for: (CIS)(MB&B)(MOBI-MN) |
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Past Enrollment Probability: Not Available |
| SECTION 01 - 2nd Quarter |
Major Readings: Wesleyan RJ Julia Bookstore
Selected readings from scientific journals such as Biochemistry, Science, Nature, Molecular Cell.
Review articles from Annual Reviews in Biochemistry, Current Opinion in Structural Biology and other similar journals.
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Examinations and Assignments:
Problem sets, One in-class presentation, one exam |
| Instructor(s): Mukerji,Ishita Times: ....R.. 01:10PM-04:00PM; Location: SCIE74; |
| Total Enrollment Limit: UNL | | SR major: UNL | JR major: UNL | | |
| Seats Available: UNL | GRAD: UNL | SR non-major: UNL | JR non-major: UNL | SO: X | FR: X |
| Drop/Add Enrollment Requests | | | | | |
| Total Submitted Requests: 0 | 1st Ranked: 0 | 2nd Ranked: 0 | 3rd Ranked: 0 | 4th Ranked: 0 | Unranked: 0 |
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