Research Methods: Behavioral Methods in Animal Research|
This is a research methods course that provides an understanding of the different approaches to animal research, particularly those using rodent models. It provides students with an understanding of the different techniques employed by researchers and the questions they address. This course provides students with HANDS-ON EXPERIENCE WITH ANIMAL RESEARCH USING RODENT MODELS. Students will learn how to handle and inject rats and will also get a sense of how to design a behavioral experiment, including the use of control groups and counterbalancing. The course will follow a lecture/discussion/lab format where students will learn about different forms of conditioning (operant/classical) and how these apply to various behavioral tasks such as operant responding, autoshaping, self-administration, locomotion testing, etc. (see readings for more examples). Class will regularly take place in the lab to provide students with hands-on experience with rats and the testing apparatuses. Students will be assigned animals for the semester that they will use to collect and analyze data during lab classes. This will be combined with regular class discussion of research articles dealing with each topic, including some of the earlier reports and more recent applications. The focus of the course will be on trying to prepare students to design and carry out behavioral/animal research in a laboratory setting.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Graded|
||Prerequisites: PSYC105 OR [NS&B213 or BIOL213 or PSYC240]
||Fulfills a Major Requirement for: (NS&B)(PSYC)(SISP)
||Past Enrollment Probability: 75% - 89%
|Major Readings: Wesleyan RJ Julia Bookstore
Readings will be based on scientific research articles, and will include some of the early or initial papers for each behavioral method (e.g. Ivan Pavlov's description of Classical Conditioning) and some recent articles showing recent uses or adaptations.
- A study of misbehavior: token reinforcement in the rat. Boakes RA et al., J Exp Anal Behav. 1978 Jan;29(1):115-34.
- Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Flagel SB, Watson SJ, Akil H, Robinson TE. Behav Brain Res. 2008 Jan 10;186(1):48-56.
- Robinson, T. E., Yager, L. M., Cogan, E. S., & Saunders, B. T. (2014). On the motivational properties of reward cues: individual differences. Neuropharmacology, 76 Pt B, 450┐459.
- Conditioned Reflexes (extract). Pavlov IP. 1927
- The behavior of organisms: an experimental analysis (extract). Skinner, B. F. Oxford, England: Appleton-Century, 1938.
- The discovery of self-stimulation and other stories. Milner PM. Neurosci Biobehav Rev. 1989 Summer-Fall;13(2-3):61-7.
- Berridge, K. C., & Robinson, T. E. (2003). Parsing reward. Trends in Neurosciences, 26(9), 507┐513.
- Robinson, T. E., & Berridge, K. C. (2008). The incentive sensitization theory of addiction: some current issues. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences, 363(1507), 3137┐3146.
- Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009). Dissecting components of reward: 'liking', ┐wanting,┐ and learning. Current Opinion in Pharmacology, 9(1), 65┐73.
- Operant self-stimulation of dopamine neurons in the substantia nigra. Rossi MA, Sukharnikova T, Hayrapetyan VY, Yang L, Yin HH. PLoS One. 2013 Jun 5;8(6):e65799.
- Drug reinforcement studied by the use of place conditioning in rat. Mucha RF, van der Kooy D, O'Shaughnessy M, Bucenieks P. Brain Res. 1982 Jul 8;243(1):91-105.
- Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Pellow S, Chopin P, File SE, Briley M. J Neurosci Methods. 1985 Aug;14(3):149-67.
- Amygdala circuitry mediating reversible and bidirectional control of anxiety.
Tye KM, et al. Nature. 2011 Mar 17;471(7338):358-62.
- Garcia, J., Lasiter, P. S., Bermudez-Rattoni, F., & Deems, D. A. (1985). A general theory of aversion learning. Annals of the New York Academy of Sciences, 443, 8┐21.
- Bernstein, I. L. (1999). Taste aversion learning: a contemporary perspective. Nutrition, 15(3), 229┐234.
- Inception of a false memory by optogenetic manipulation of a hippocampal memory engram.
Liu X, Ramirez S, Tonegawa S. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130142.
- Progressive ratio as a measure of reward strength. Hodos W. Science. 1961 Sep 29;134(3483):943-4.
- Ahmed, S. H., & Koob, G. F. (1998). Transition from moderate to excessive drug intake: change in hedonic set point. Science, 282(5387), 298┐300.
- Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004). Evidence for addiction-like behavior in the rat. Science, 305(5686), 1014┐1017.
- Chen, B. T., Yau, H.-J., Hatch, C., Kusumoto-Yoshida, I., Cho, S. L., Hopf, F. W., & Bonci, A. (2013). Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature, 496(7445), 359┐362.
|Examination and Assignments: |
Two exams consisting of multiple choice and short answer questions; Lab reports and analyses of data collected in the lab; Participation and in class (directing) discussion.
|Instructor(s): Robinson,Mike Times: .M.W.F. 09:50AM-10:40AM; Location: JUDD113; |
|Total Enrollment Limit: 15||SR major: 2||JR major: 2|| || |
|Seats Available: 1||GRAD: X||SR non-major: 0||JR non-major: 0||SO: 6||FR: 5|
|Web Resources: |
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