Cell Migration in Development and Disease|
What do the formation of an embryo, the healing of a wound, the surveillance of the immune system, and the invasion of metastatic cancer all have in common? Each of these processes requires the coordinated movement of cells, alone or in groups. In this course, we will learn how and why cells move, and explore what happens when they stop moving properly. We will build up our knowledge from "small" to "large," spanning biological scales from molecules to tissues. Topics will include: (1) the biomolecules of migration: cytoskeleton, focal adhesions, molecular motors; (2) cellular locomotion: protrusion, adhesion, contraction, retraction; (3) cell mechanics and force generation; (4) collective motions during morphogenesis and repair; (5) mechanisms for steering migration: chemotaxis, haptotaxis, galvanotaxis, durotaxis, etc; (6) cancer as a disease of aberrant cell migration. Throughout the course we will emphasize model systems, experimental design, and technology and measurement techniques. We will focus on seminal works, with attention paid to how these works rippled forward in time, along with cutting edge research.
||Gen Ed Area Dept:
|Course Format: Discussion||Grading Mode: Graded|
||Fulfills a Major Requirement for: (BIOL)(IDEA-MN)(INFO-MN)(MOBI-MN)
||Past Enrollment Probability: 90% or above
|Major Readings: Wesleyan RJ Julia Bookstore
Readings will be provided via Moodle
|Examinations and Assignments: |
Grading will be based on a diverse set of opportunities to demonstrate your learning, including short responses to readings, in class presentations and participation, and a final project.
|Additional Requirements and/or Comments: |
|Instructor(s): Mitchel,Jennifer Times: .M.W... 02:50PM-04:10PM; Location: SCIE339; |
|Total Enrollment Limit: 16||SR major: 5||JR major: 5|| || |
|Seats Available: 2||GRAD: 2||SR non-major: 2||JR non-major: 2||SO: 0||FR: X|
|Drop/Add Enrollment Requests|
|Total Submitted Requests: 0||1st Ranked: 0||2nd Ranked: 0||3rd Ranked: 0||4th Ranked: 0||Unranked: 0|