Spring 2019 not offered
|Certificates: Molecular Biophysics, Molecular Biophysics|
This course will cover how a spectrometer works as well as the theory and application of NMR experiments. The topics will include one-dimensional proton and heteronuclear experiments as well as decoupling. The course will begin with how the spectrometer works and how data processing is carried out, as well as how to calibrate the spectrometer and shim the magnet. The one-dimensional TOCSY and NOESY experiments will then be covered. The course will also cover heteronuclear and homonuclear two-dimensional NMR experiments. The experiments will include two-dimensional DQFCOSY, TOCSY, NOESY, and ROESY proton experiments as well as heteronuclear experiments to correlate the chemical shifts of protons and heteronuclei, as well as how to select heteronuclear resonances on the basis of the number of directly attached protons.
The course will consist of lectures as well as a laboratory component in which the Mercury 300 will be used to obtain data that will be analyzed using the methods developed in the lecture part of the course. This course is specifically aimed at general users of the Mercury spectrometer who wish to learn how to carry out and analyze advanced one-dimensional and two-dimensional NMR experiments.
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|Course Format: Lecture / Discussion||Grading Mode: Graded|
||Fulfills a Major Requirement for: (CHEM-MN)(CHEM-Track A)(CHEM-Track B)(CMB)(MB&B)
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