This course will investigate the structure of the eukaryotic chromosome and consider how that structure influences fundamental biological processes such as recombination, DNA replication, chromosome segregation and gene expression. We will also examine the elements necessary for maintaining and propagating chromosomes, including telomeres, centromeres, and replication origins. We will use primary sources from scientific literature and a discussion format to appreciate current approaches, conclusions, and unresolved issues in the field. This is a half semester course. It will be taught the first half of the semester. |