Fall 2012 not offered
|Certificates: Informatics and Modeling, Molecular Biophysics|
An exploration of the structure and dynamics of biological molecules and their interactions based on fundamental concepts from physical chemistry (thermodynamics, quantum mechanics, statistical mechanics, and chemical dynamics), including experimental methods (crystallography, NMR, UV, IR, and Raman spectroscopies) and computational methods (molecular dynamics and Monte Carlo simulations, continuum electrostatics, and structural bioinformatics). The course will be taught on the basis of case studies drawn from the current literature with an emphasis on explicating the capabilities and limitations of using these various methods to understand structure determination and prediction, binding and specificity of ligand interactions, protein folding and DNA bending having implications with respect to biological control processes. An introduction to and background material on the various theories, methodologies, and experimental techniques will be provided to accommodate cross-disciplinary undergraduate and graduate students. This course is intended to be a suitable venue for chemistry and physics students to gain an appreciation for biological applications of their disciplines and for students in the life sciences to gain a familiarity with physico-chemical aspects of modern molecular biology.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Student Option|
||Prerequisites: CHEM141 OR CHEM143 OR PHYS111 OR PHYS113
||Fulfills a Major Requirement for: (CHEM-Track A)(CHEM-Track B)
MOLECULAR DYNAMICS SIMULATION: ELEMENTARY METHODS, J. M. Haile;
MOLECULAR MODELING: PRINCIPLES AND APPLICATIONS, A. R. Leach
|Examination and Assignments: |
Computer-based homework exercises.