Spring 2022 not offered
This course is addressed to undergraduate and graduate students interested in biological chemistry and structural biology. The course presents thermodynamic methods currently used to relate structure to function in biological molecules. Topics include binding curves, chemical ligand linkages, binding polynomial, cooperativity, site-specific binding processes, and allosteric effects. Several models for allosteric systems, such as the Monod-Wyman-Changeux model, the induced-fit model, and the Pauling model, are analyzed in detail. Applications of these models are illustrated for functional regulation of respiratory proteins and for protein-nucleic-acid complexes involved in control of gene expression.
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|Course Format: Lecture / Discussion||Grading Mode: |
||Prerequisites: (MATH121 AND MATH122)
||Fulfills a Major Requirement for: (CHEM-MN)(CHEM-Track A)(CHEM-Track B)(MB&B)(MOBI-MN)