Fall 2010 not offered
NS&B 324, BIOL 524, NS&B 524|
The molecular mechanisms underlying the adaptive (and sometimes maladaptive) nature of brain function are beginning to be elucidated. This course is designed to provide the student with a mechanistic understanding of normal and pathological brain function and how drugs modulate neurological and psychiatric disease. Topics will include cell biology of the neuron synaptic transmission; neurotransmitters; modulation of synaptic transmission; tyrosine kinases; G-protein-coupled receptors serotonin, dopamine, acetylcholine, opiate receptors; cell death; and molecular mechanisms of neurological diseases. The first three-quarters of the course will be in lecture format. The remaining quarter will be in the format of a journal club where selected articles will be presented and discussed.
Interpretation, Logical Reasoning
Students utilize information provided in lecture to formulate hypotheses of brain disorders and drug action.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Graded|
||Prerequisites: [BIOL182 or MB&B182] AND [NS&B213 or BIOL213 or PSYC240]
||Fulfills a Major Requirement for: (BIOL)(NS&B)(SISP)
Julien, Robert M., A PRIMER OF DRUG ACTION, 10th ed. (optional)
Eric J. Nestler, Steven E. Hyman, Robert C. Malenka, MOLECULAR BASIS OF NEUROPHARMACOLOGY: A FOUNDATION FOR CLINICAL NEUROSCIENCE, 2nd ed. (Paperback)
|Examinations and Assignments: |
Students will be graded on three exams, a cumulative final exam, and written assignments comprised of a 1-2 page summary of each selected article to be discussed in class.
|Additional Requirements and/or Comments: |
Though the lectures will be the same for undergraduate and graduate students, and all students will be expected to present discussions on topics of their choice, exams and expectations will be different for graduate students, who will be graded on a separate curve.
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