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Protein Folding: From Misfolding to Disease

MB&B 535
Fall 2018
Section: 01  
Crosslisting: MB&B 335, CHEM 335, CHEM 535
Certificates: Molecular Biophysics
Course Cluster: Health Studies

Amyloidogenesis, the process by which proteins and peptides misfold to form amyloid fibers, is at the root of several different diseases, including Parkinson's disease, Alzheimer's disease, mad cow disease, and type II diabetes to name a few. This course will focus on current research in the field that seeks to understand why a functional, well-folded protein adopts the misfolded amyloid form. In the course of discussing the misfolded nature of these proteins, we will review central elements of protein structure and stability to better understand the protein-folding landscape and the process of misfolding. We will also discuss how the process of misfolding leads to the different diseases and disease pathologies. We will read current literature that studies the molecular nature of these diseases and discuss the strategies used to detect, identify and study these misfolded proteins in the body and in the test-tube.
Credit: 1 Gen Ed Area Dept: NSM MB&B
Course Format: Lecture / DiscussionGrading Mode: Graded
Level: GRAD Prerequisites: MB&B208 OR MB&B325
Fulfills a Major Requirement for: (CIS)(MB&B)(MOBI-MN)
Past Enrollment Probability: 90% or above

Last Updated on APR-01-2023
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