Stochastic Biology: Randomness and Order in Gene Regulation|
While much of biology is discussed with assumptions of "determinism" (e.g., the cell is instructed to express a transcription factor that activates a downstream gene in a deterministic and entirely predictable way) and "homogeneity" (e.g., a population of cells all behaving synchronously in the same way), there is a growing appreciation that many biological outcomes are, in fact, statistical phenomena and stochastic in nature. In this half-credit module, we will discuss stochastic behavior in biology from the perspective of gene expression. A focus will be on emerging molecular and cellular techniques that enable observation of stochastic behavior at a single-cell resolution, thus permitting researchers to characterize molecular behavior as it actually occurs, as opposed to averaging a behavior across a population of otherwise diverse individuals. Insights on stochastic behaviors have far-reaching implications in biology, challenging long-held perspectives on transcription, replication, signal transduction, enzymatics, disease states (like cancer), stems cells, cell differentiation, aging, adaptive evolution, etc. This course will focus primarily on one of these: stochastic behavior in transcription and chromosome dynamics and its implications to understanding cell and tissue behavior.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Graded|
||Fulfills a Major Requirement for: (MB&B)
||Past Enrollment Probability: 90% or above
|SECTION 01 - 1st Quarter|
|Major Readings: Wesleyan RJ Julia Bookstore
Primary literature (various select papers)
|Examination and Assignments: |
In-class presentation, research proposal, one in-class test
Student work will include in-class presenting and discussing recently published papers, as well as a final assignment to write a mini research proposal.
|Additional Requirements and/or Comments: |
Recommended prerequisite for advanced undergraduates is MB&B 208 or MB&B 333 or equivalent with solid background on the topic of transcription.
|Instructor(s): Lane,Robert P. Times: ..T.R.. 01:20PM-02:40PM; Location: SCIE141; |
|Total Enrollment Limit: 19||SR major: 6||JR major: 5|| || |
|Seats Available: 10||GRAD: 8||SR non-major: 0||JR non-major: 0||SO: 0||FR: 0|