Molecules to Medicine|
BIOL 342, CIS 342, MB&B 342|
|Certificates: Molecular Biophysics|
This course will explore the process of drug development, including target selection, lead discovery using computer-based methods and combinatorial chemistry/high-throughput screening, organic synthesis, bioavailability, clinical trials, and other factors (some economics and politics) involved in bringing a drug to the marketplace. Critical consideration of the variables to contend with at each step will be described and discussed, including aspects of research ethics and patent law. The basic science of molecular recognition, computer-aided drug design, and the role of factors from synthetic chemistry to toxicology will be presented. Case studies of the development of drugs recently successful in making the journey from molecule to medicine will be discussed, as well as the story of some that did not, and why. Emerging new design strategies such as fusion-protein therapies, crisper technology, and enhanced use of rational design and combinatorial methods will be emphasized, and how pharmaceutical research is evolving in the postgenomic era, particularly with biologics. Job opportunities in the pharmaceutical industry will be discussed.
||Gen Ed Area Dept:
|Course Format: Lecture / Discussion||Grading Mode: Graded|
||Prerequisites: CHEM252 OR MBB208
||Fulfills a Major Requirement for: (CIS)(MB&B)(MOBI-MN)
||Past Enrollment Probability: 90% or above
|Major Readings: Wesleyan RJ Julia Bookstore
(R.J. Julia Bookstore):
Corey, E.J. MOLECULES AND MEDICINE (Wiley & Co)
P. Griswell, MOLECULAR THERAPEUTICS: 21ST CENTURY MEDICINE (Wiley & Co).
|Examinations and Assignments: |
Weekly Response Papers, Midterm Exam, Independent Term Project, Final Examination.
|Additional Requirements and/or Comments: |
This course may be taken by permission of the instructors. Petition via Email and cc all instructors. Please attend class before purchasing textbooks (in case of updates).
Prerequisites: Organic Chemistry (CHEM 252) or Molecular Biology (Biol/MBB 208).
|Instructor(s): Langley,David Ray Thayer,Kelly Marie Beveridge,David L. Times: ..T.... 07:10PM-10:00PM; Location: HALL84; |
|Total Enrollment Limit: 20||SR major: 7||JR major: 7|| || |
|Seats Available: 5||GRAD: X||SR non-major: X||JR non-major: X||SO: 6||FR: X|
|Drop/Add Enrollment Requests|
|Total Submitted Requests: 0||1st Ranked: 0||2nd Ranked: 0||3rd Ranked: 0||4th Ranked: 0||Unranked: 0|